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Index > Protein center > AKR1B10(Gene name) > Human
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  • AKR1B10 (Gene name),
  • Aldo-keto reductase family 1 member B10 (Protein name ),  AK1BA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    AKR1B10(AKR1B11);
    Protein name:
    Aldo-keto reductase family 1 member B10;
    Alternative:
    Aldose reductase-like;ARL-1;Small intestine reductase(SI reductase);Aldose reductase-related protein(ARP;hARP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    316
    Sequence:
    50:
    MATFVELSTK | AKMPIVGLGT | WKSPLGKVKE | AVKVAIDAGY | RHIDCAYVYQ | 
    100:
    NEHEVGEAIQ | EKIQEKAVKR | EDLFIVSKLW | PTFFERPLVR | KAFEKTLKDL | 
    150:
    KLSYLDVYLI | HWPQGFKSGD | DLFPKDDKGN | AIGGKATFLD | AWEAMEELVD | 
    200:
    EGLVKALGVS | NFSHFQIEKL | LNKPGLKYKP | VTNQVECHPY | LTQEKLIQYC | 
    250:
    HSKGITVTAY | SPLGSPDRPW | AKPEDPSLLE | DPKIKEIAAK | HKKTAAQVLI | 
    300:
    RFHIQRNVIV | IPKSVTPARI | VENIQVFDFK | LSDEEMATIL | SFNRNWRACN | 
    316:
    VLQSSHLEDY | PFNAEY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    STRING:
    9606.ENSP00000352584
    String:
    O60218
    MIM:
    604707
    Pfam:
    PF00248
    UniGene:
    Hs.116724
    SMR:
    O60218
    KEGG:
    hsa:57016
    Uniprot:
    O60218
     
    FOR
    ELISA Kit for Human Aldo-keto reductase family 1 member B10
    Cat.:
    E10867h
    Price:
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    Manual:
    Looking for manual.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Aldo-keto reductase family 1 member B10
    Cat.:
    U10867h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Aldo-keto reductase family 1 member B10
    Cat.:
    P10867Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Aldo-keto reductase family 1 member B10
    Protein for Human Aldo-keto reductase family 1 member B10

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Identification and characterization of a novel human aldose reductase-like gene."
      Cao D. , Fan S.T. , Chung S.S.M.
      J. Biol. Chem.273:11429-11435(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-313
      tissue: Liver tumor.
    2. 2.
      "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family."
      Hyndman D.J. , Flynn T.G.
      Biochim. Biophys. Acta1399:198-202(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Small intestine.
    3. 3.
      "Representational difference analysis based identification and full-length sequencing of a gene of the aldo-ketoreductase family strongly overexpressed in hepatocellular carcinoma."
      Heringlake S.
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-313
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-313
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-313
    6. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Human chromosome 7: DNA sequence and biology."
      Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
      Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-313
      tissue: Pancreas.
    10. 10.
      "New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma."
      Scuric Z. , Stain S.C. , Anderson W.F. , Hwang J.-J.
      Hepatology27:943-950(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-316;VARIANT ASP-313
    11. 11.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-125 AND LYS-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway."
      Luo D.X. , Huang M.C. , Ma J. , Gao Z. , Liao D.F. , Cao D.
      Biochem. J.438:71-80(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    13. 13.
      "Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10."
      Gallego O. , Ruiz F.X. , Ardevol A. , Dominguez M. , Alvarez R. , de Lera A.R. , Rovira C. , Farres J. , Fita I. , Pares X.
      Proc. Natl. Acad. Sci. U.S.A.104:20764-20769(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) IN COMPLEX WITH TOLRESTAT AND NADP;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;MUTAGENESIS OF LYS-125 AND VAL-301
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-313;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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